Anti-Hyperglycemic And Antidyslipidemic Potential Of Azadirachta indica Leaf Extract In STZ- Induced Diabetes Mellitus

Azadirachta indica , an Indian medicinal plant, has been studied for its role in diabetes and its effect on lipid profile. This study was conducted to elucidate whether treatment of Azadirachta indica leaf extract after streptozotocin (STZ) induced diabetes has anti-hyperglycemic and anti-dyslipidaemic action or not. The experiment involved four groups of rat; one group was control group, second diabetic control, third diabetic group received alcoholic extract of Azadirachta indica and fourth diabetic group received Glibenclamide as a reference standard. Oral glucose tolerance test was performed before induction of diabetes. Blood was collected by retro-orbital puncture for glucose estimation, and to evaluate serum triglyceride, total cholesterol, HDL-cholesterol, LDL-cholesterol levels. Blood Glucose level as well as serum lipid profile parameters such as total-cholesterol, triglyceride, low-density lipoprotein and very low-density lipoprotein cholesterol were also elevated, whereas, the level of high-density lipoprotein-cholesterol was reduced significantly (P<0.05) in diabetic rats . Ethanolic extract of A.indica after induction of diabetes, normalized glucose level and lipid profile. It can be concluded that STZ-induced hyperglycaemia can be ameliorated by treatment with ethanolic extract of A indica. A.indica ethanolic leaves extract after diabetic induction, reverses dyslipidaemia.